2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131269R
    Febuxostat impurity 7 (Standard)
    Cinnamyl Alcohol (Standard) is the analytical standard of Cinnamyl Alcohol. This product is intended for research and analytical applications. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity.
    Febuxostat impurity 7 (Standard)
  • HY-145482
    W36017
    W3601 is the impurity of Lidocaine. W3601 exhibits nerve blocking activity with the pKa of 7.4.
    W36017
  • HY-143988S
    Nefazodone impurity 3-d6
    Nefazodone impurity 3-d6 is the deuterium labeled Nefazodone impurity 3.
    Nefazodone impurity 3-d<sub>6</sub>
  • HY-135389S
    Desmethyl Levofloxacin-d8 hydrochloride
    Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
    Desmethyl Levofloxacin-d<sub>8</sub> hydrochloride
  • HY-119696R
    MTIC (Standard)
    MTIC (Standard) is the analytical standard of MTIC. This product is intended for research and analytical applications. MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1][2][3][4].
    MTIC (Standard)
  • HY-N10382
    20,26-Dihydroxyecdysone
    20,26-Dihydroxyecdysone is a predominant ecdysteroid metabolite.
    20,26-Dihydroxyecdysone
  • HY-136457
    2-NP-AHD
    2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents.
    2-NP-AHD
  • HY-137107
    Radafaxine
    Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion.
    Radafaxine
  • HY-133110
    Afatinib N-Oxide
    Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor.
    Afatinib N-Oxide
  • HY-129099
    N-Desmethyltamoxifen
    N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
    N-Desmethyltamoxifen
  • HY-143938S
    Cyclobenzaprine impurity 2-d3 hydrochloride
    Cyclobenzaprine impurity 2-d3 (hydrochloride) is the deuterium labeled Cyclobenzaprine impurity 2 hydrochloride.
    Cyclobenzaprine impurity 2-d<sub>3</sub> hydrochloride
  • HY-172560
    6β-Oxycodol N-oxide
    6β-Oxycodol N-oxide is an opioid derivative and a metabolite of Oxycodone, which can be detected in urine.
    6β-Oxycodol N-oxide
  • HY-171732
    FANFT
    FANFT is an orally active and potent uroepithelial carcinogen. FANFT is metabolized to ANFT in vivo, which induces gene mutations and malignant cell transformation. FANFT efficiently induces bladder tumors in mice.
    FANFT
  • HY-120190
    Citreoindole
    Citreoindole is a diketopiperazine metabolite isolated from a hybrid cell fusion of two strains of P. citreovirde that is cytotoxic in vitro against HeLa cells at 8.4 μM.
    Citreoindole
  • HY-122317
    Menthol glucuronide
    Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation.
    Menthol glucuronide
  • HY-W766163
    7-Hydroxy coumarin glucuronide-d5 sodium
    7-Hydroxy coumarin glucuronide-d5 sodium is the deuterium labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin.
    7-Hydroxy coumarin glucuronide-d<sub>5</sub> sodium
  • HY-12767S
    4-Hydroxyphenyl Carvedilol-d5
    4-Hydroxyphenyl Carvedilol-d5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.
    4-Hydroxyphenyl Carvedilol-d<sub>5</sub>
  • HY-151930S1
    8′-Hydroxy ABA-d2
    8′-Hydroxy ABA-d2 is the deuterium labeled 8’-Hydroxy ABA.
    8′-Hydroxy ABA-d<sub>2</sub>
  • HY-106894
    Lufironil
    Lufironil (HOE 077) is a prolyl 4-hydroxylase inhibitor. Lufironil is developed for the research of chronic liver diseases including alcoholic hepatitis and liver cirrhosis.
    Lufironil
  • HY-N15717
    (erythro) 1′,2′-Dihydroxyasarone
    (erythro) 1′,2′-Dihydroxyasarone is a metabolite of Beta-asarone (HY-N1501) and can also be isolated from the roots of Acorus tatarinowii. (erythro) 1′,2′-Dihydroxyasarone can form glucuronic acid conjugates in vivo and be excreted in urine. (erythro) 1′,2′-Dihydroxyasarone can serve as a marker for the metabolism and toxic risk assessment of Beta-asarone.
    (erythro) 1′,2′-Dihydroxyasarone
Cat. No. Product Name / Synonyms Application Reactivity